Serotypes and penicillin susceptibility of pneumococci isolated from blood.

Journal Article (Journal Article)

To learn the prevalence of penicillin-resistant pneumococci and the distribution of serotypes in proved pneumococcal infections, we studied 98 pneumococci recovered from blood over a 4-year period. Penicillin susceptibility was determined by the agar dilution method. Serotyping was done by the capsular swelling (quellung) test. Only one strain showed diminished susceptibility to penicillin (minimal inhibitory concentration, 0.12 micrograms/ml). Twenty-three different serotypes were identified; types 3, 4, 6, 8, 9, 14, and 19 were the most frequent. Type 4 was the most common serotype. Sixty-two percent of strains were serotypes included in a recently licensed 14-type pneumococcal polysaccharide vaccine (Pneumovax, Merck), and an additional 16% were antigenically related serotypes. Even though penicillin-resistant strains of pneumococci may rarely cause bacteremic pneumococcal infection, we suggest that isolates from cerebrospinal fluid, blood, and other normally sterile body fluids be tested for penicillin susceptibility. Inclusion of additional serotypes in future pneumococcal polysaccharide vaccines should be based on the current distribution of serotypes in large series of proved pneumococcal infections.

Full Text

Duke Authors

Cited Authors

  • Lauer, BA; Reller, LB

Published Date

  • March 1, 1980

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 242 - 244

PubMed ID

  • 7380999

Pubmed Central ID

  • PMC273371

International Standard Serial Number (ISSN)

  • 0095-1137

Digital Object Identifier (DOI)

  • 10.1128/jcm.11.3.242-244.1980


  • eng

Conference Location

  • United States