Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis.

Journal Article (Journal Article)

To compare the in vitro activity of cefamandole with ampicillin, cefoxitin, and gentamicin, each antimicrobial was tested against 419 bacteria isolated from the blood of patients with proved sepsis. Cefamandole was active against all gram-positive cocci except the enterococci. Most Enterobacteriaceae were inhibited by both cefamandole and cefoxitin. Cefamandole showed an activity similar to ampicillin against Haemophilus influenzae. The percent of blood culture isolated considered susceptible to the drugs tested were as follows: cefamandole 79%, cefoxitin 78%, ampicillin 55% and gentamicin 81%. None of the drugs tested would be adequate alone for treatment of sepsis of unknown etiology based on in vitro susceptibility data.

Full Text

Duke Authors

Cited Authors

  • Mirrett, S; Reller, LB

Published Date

  • 1980

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 436 - 445

PubMed ID

  • 7408556

International Standard Serial Number (ISSN)

  • 0009-3157

Digital Object Identifier (DOI)

  • 10.1159/000237940


  • eng

Conference Location

  • Switzerland