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Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis.

Publication ,  Journal Article
Mirrett, S; Reller, LB
Published in: Chemotherapy
1980

To compare the in vitro activity of cefamandole with ampicillin, cefoxitin, and gentamicin, each antimicrobial was tested against 419 bacteria isolated from the blood of patients with proved sepsis. Cefamandole was active against all gram-positive cocci except the enterococci. Most Enterobacteriaceae were inhibited by both cefamandole and cefoxitin. Cefamandole showed an activity similar to ampicillin against Haemophilus influenzae. The percent of blood culture isolated considered susceptible to the drugs tested were as follows: cefamandole 79%, cefoxitin 78%, ampicillin 55% and gentamicin 81%. None of the drugs tested would be adequate alone for treatment of sepsis of unknown etiology based on in vitro susceptibility data.

Duke Scholars

Published In

Chemotherapy

DOI

ISSN

0009-3157

Publication Date

1980

Volume

26

Issue

6

Start / End Page

436 / 445

Location

Switzerland

Related Subject Headings

  • Sepsis
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Gentamicins
  • Cefoxitin
  • Cefamandole
  • Bacteria
  • Anti-Bacterial Agents
  • Ampicillin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mirrett, S., & Reller, L. B. (1980). Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis. Chemotherapy, 26(6), 436–445. https://doi.org/10.1159/000237940
Mirrett, S., and L. B. Reller. “Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis.Chemotherapy 26, no. 6 (1980): 436–45. https://doi.org/10.1159/000237940.
Mirrett, S., and L. B. Reller. “Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis.Chemotherapy, vol. 26, no. 6, 1980, pp. 436–45. Pubmed, doi:10.1159/000237940.
Journal cover image

Published In

Chemotherapy

DOI

ISSN

0009-3157

Publication Date

1980

Volume

26

Issue

6

Start / End Page

436 / 445

Location

Switzerland

Related Subject Headings

  • Sepsis
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Gentamicins
  • Cefoxitin
  • Cefamandole
  • Bacteria
  • Anti-Bacterial Agents
  • Ampicillin