Detection of bloodstream pathogens in a bacille Calmette-Guérin (BCG)-vaccinated pediatric population in Malawi: a pilot study.

Published

Journal Article

Children in Malawi receive bacille Calmette-Guérin (BCG) vaccination within the first 3 days of life. Thus, we hypothesized that Malawian children infected with the human immunodeficiency type 1 virus (HIV-1) might be particularly vulnerable to dissemination of the BCG Mycobacterium bovis strain with which they were vaccinated. Following informed consent by parents, we studied children admitted to a Malawi general hospital during the 1998 wet and dry seasons. Blood from cohorts of acutely ill children was cultured for bacteria, including mycobacteria, and fungi, and tested for anti-HIV-1 antibodies. It was shown that non-typhi Salmonella and Escherichia coli were the predominant bloodstream pathogens during the wet and dry seasons, and that bloodstream dissemination of the BCG M. bovis strain is uncommon in HIV-1-infected children who receive the BCG vaccine.

Full Text

Duke Authors

Cited Authors

  • Archibald, LK; Nwanyanwu, O; Kazembe, PN; Mwansambo, C; Bell, M; Dobbie, H; Reller, LB; Jarvis, WR

Published Date

  • March 2003

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 234 - 238

PubMed ID

  • 12667257

Pubmed Central ID

  • 12667257

Electronic International Standard Serial Number (EISSN)

  • 1469-0691

International Standard Serial Number (ISSN)

  • 1198-743X

Digital Object Identifier (DOI)

  • 10.1046/j.1469-0691.2003.00517.x

Language

  • eng