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Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy.

Publication ,  Journal Article
Dewhirst, MW; Sim, DA; Forsyth, K; Grochowski, KJ; Wilson, S; Bicknell, E
Published in: Int J Hyperthermia
1985

Forty-three dogs with primary malignant melanoma were randomized to receive radiotherapy alone (XRT) or hyperthermia plus radiotherapy (delta + XRT). Tumour responses were analysed in terms of complete response rates, rate of one year disease free survival and the incidence and time to develop distant metastasis. The frequency of complete responses (CR) was greater with adjuvant heat (76 per cent vs 21 per cent for XRT; P = 0.001). A trend towards an improvement in one year disease free survival was observed with delta + XRT (23.8 per cent) as compared with XRT (7.7 per cent), but the difference was not statistically significant. The frequency of distant metastases was not different between the two treatments. Descriptors of intratumoural temperatures achieved during therapy indicated that higher CR rates could be achieved with higher minima. When minima were less than and greater than 20 Equivalent minutes at 43 degrees C (Eq43) the CR rates were 64 and 90 per cent, respectively. One year disease free survival rates and frequencies of distant metastases seemed to be correlated with the intratumoural temperatures as well. This was reflected in analyses examining temperature minima and maxima. Examination of patterns of failure suggested that the most plausible explanation for the correlation between intratumoural temperature and metastases was the high local failure rate (70 per in the heated group). The results of this study emphasize the need for further investigation of the influence of local hyperthermia as a part of curative therapy on the frequency of distant metastases.

Duke Scholars

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

1985

Volume

1

Issue

3

Start / End Page

219 / 234

Location

England

Related Subject Headings

  • Time Factors
  • Skin Neoplasms
  • Regression Analysis
  • Random Allocation
  • Prognosis
  • Pharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Mouth Neoplasms
  • Melanoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dewhirst, M. W., Sim, D. A., Forsyth, K., Grochowski, K. J., Wilson, S., & Bicknell, E. (1985). Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy. Int J Hyperthermia, 1(3), 219–234. https://doi.org/10.3109/02656738509029287
Dewhirst, M. W., D. A. Sim, K. Forsyth, K. J. Grochowski, S. Wilson, and E. Bicknell. “Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy.Int J Hyperthermia 1, no. 3 (1985): 219–34. https://doi.org/10.3109/02656738509029287.
Dewhirst MW, Sim DA, Forsyth K, Grochowski KJ, Wilson S, Bicknell E. Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy. Int J Hyperthermia. 1985;1(3):219–34.
Dewhirst, M. W., et al. “Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy.Int J Hyperthermia, vol. 1, no. 3, 1985, pp. 219–34. Pubmed, doi:10.3109/02656738509029287.
Dewhirst MW, Sim DA, Forsyth K, Grochowski KJ, Wilson S, Bicknell E. Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy. Int J Hyperthermia. 1985;1(3):219–234.
Journal cover image

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

1985

Volume

1

Issue

3

Start / End Page

219 / 234

Location

England

Related Subject Headings

  • Time Factors
  • Skin Neoplasms
  • Regression Analysis
  • Random Allocation
  • Prognosis
  • Pharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Mouth Neoplasms
  • Melanoma