Determination of continuous atracurium infusion rate in dogs undergoing whole-body hyperthermia.

Journal Article

Infusion rates for atracurium were calculated from multiple bolus injection data for normothermic (38 degrees C; n = 4) and hyperthermic (42 degrees C; n = 14) dogs anesthetized with thiopental and oxymorphone while undergoing whole-body hyperthermia treatment. The calculated infusion rate for atracurium at 38 degrees C was 6.2 +/- 0.3 micrograms/kg/min and the calculated infusion rate at 42 degrees C was 8.5 +/- 0.4 micrograms/kg/min. Infusion of atracurium at the calculated infusion rate of 8.5 micrograms/kg/min produced an estimated 90-100% neuromuscular blockade during heating from 38-42 degrees C and at 42 degrees C. Following discontinuation of the infusion and cooling to 38 degrees C, neuromuscular function returned to normal within 20 min with no evidence of recurarization. Atracurium infusion rates appear to be linear and related to body temperature from 26-42 degrees C. Clinically useful neuromuscular blockade in dogs may be obtained during whole-body hyperthermia by utilizing the 42 degrees C atracurium infusion rate throughout the 38-42 degrees C heating phase.

Full Text

Duke Authors

Cited Authors

  • Meyer, RE; Page, RL; Thrall, DE; Dewhirst, MW; Vose, DL

Published Date

  • November 1986

Published In

Volume / Issue

  • 46 / 11

Start / End Page

  • 5599 - 5601

PubMed ID

  • 3756907

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States