Phase I evaluation of doxorubicin and whole-body hyperthermia in dogs with lymphoma.

Published

Journal Article

Fifteen previously untreated dogs with histologically confirmed, high-grade multicentric lymphoma were entered into a phase I study to evaluate combined doxorubicin and whole-body hyperthermia (DOX/WBH). Groups of three, four, and eight dogs were treated with whole-body hyperthermia and concurrent doxorubicin at 12 mg/m2, 24 mg/m2 and 30 mg/m2, respectively, after one doxorubicin induction dose at 30 mg/m2. Plateau temperature (42 +/- 0.1 degree C) was maintained for 90 minutes using a radiant heating device. A total of five DOX/WBH treatments per dog were planned, and these were given every 21 days. Treatment-related toxicity was not seen in the 12-mg/m2 doxorubicin dose group. Tumor progression prohibited administration of more than three DOX/WBH treatments to any dog in the 12-mg/m2 group. Premature ventricular contractions developed after the fifth treatment in one of the four dogs treated with 24 mg/m2 of doxorubicin. Two dogs (25%) in the 30-mg/m2 dose group had treatment-related toxicity. One dog experienced acute serious myelosuppression 1 week after the third treatment. This dog received all planned DOX/WBH treatments. Asymptomatic cardiac toxicosis consisting of decreased ejection fraction and fractional shortening developed in the second dog. This dog received only two DOX/WBH treatments. The three dogs treated at 12 mg/m2 had partial responses of short duration (60-83 days). Four dogs treated at 24 mg/m2 had complete responses for 150, 164, 186, and 200 days. Eight dogs treated at 30 mg/m2 had complete responses with a mean and median duration of 241 and 190 days, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Full Text

Duke Authors

Cited Authors

  • Novotney, CA; Page, RL; Macy, DW; Dewhirst, MW; Ogilvie, GK; Withrow, SJ; McEntee, MC; Heidner, GL; Allen, SA; Thrall, DE

Published Date

  • July 1992

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 245 - 249

PubMed ID

  • 1522556

Pubmed Central ID

  • 1522556

International Standard Serial Number (ISSN)

  • 0891-6640

Digital Object Identifier (DOI)

  • 10.1111/j.1939-1676.1992.tb00346.x

Language

  • eng

Conference Location

  • United States