Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences.

Published

Journal Article

During transcription of the human immunodeficiency virus type 1 provirus, polyadenylation signals present in the 5' long terminal repeat (LTR) are disregarded while the identical polyadenylation signals present in the 3' LTR are utilized efficiently. As both transcribed LTR sequences contain all signals known to be required for efficient polyadenylation, the basis for this differential utilization has been unclear. Here, we describe experiments that suggest that transcribed sequences present within the human immunodeficiency virus type 1 LTR U3 region act in cis to enhance polyadenylation within the 3' LTR.

Full Text

Duke Authors

Cited Authors

  • Brown, PH; Tiley, LS; Cullen, BR

Published Date

  • June 1991

Published In

Volume / Issue

  • 65 / 6

Start / End Page

  • 3340 - 3343

PubMed ID

  • 1851882

Pubmed Central ID

  • 1851882

International Standard Serial Number (ISSN)

  • 0022-538X

Language

  • eng

Conference Location

  • United States