The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site.

Published

Journal Article

The Bel-1 protein of human foamy virus can activate transcription directed by the long terminal repeat (LTR) promoter of human immunodeficiency virus type 1 (HIV-1). The target sequence for Bel-1 is shown to lie within the HIV-1 LTR U3 region but does not coincide with any previously described factor-binding site. Gene expression directed by an HIV-1 LTR lacking functional sites for the inducible cellular transcription factor NF-kappa B was activated over 100-fold by coexpression of Bel-1. These observations suggest that Bel-1 has the potential to significantly enhance the level of HIV-1 gene expression in cells dually infected with HIV-1 and human foamy virus.

Full Text

Duke Authors

Cited Authors

  • Keller, A; Garrett, ED; Cullen, BR

Published Date

  • June 1992

Published In

Volume / Issue

  • 66 / 6

Start / End Page

  • 3946 - 3949

PubMed ID

  • 1316494

Pubmed Central ID

  • 1316494

International Standard Serial Number (ISSN)

  • 0022-538X

Language

  • eng

Conference Location

  • United States