Nuclear mRNA export: insights from virology.


Journal Article (Review)

To maximize the production of progeny virions, several viruses have evolved mechanisms that promote the selective nuclear export of viral mRNA transcripts while, in some cases, inhibiting the export of cellular mRNAs. To achieve this goal, viruses have evolved regulatory proteins and cis-acting RNA elements that selectively interact with key cellular nuclear export factors. Efforts to identify the cellular targets of these viral proteins and RNA elements have led to the identification of Crm1 and Tap as essential human nuclear RNA-export factors and continue to provide insights into how mRNAs are selected for export

Full Text

Duke Authors

Cited Authors

  • Cullen, BR

Published Date

  • August 2003

Published In

Volume / Issue

  • 28 / 8

Start / End Page

  • 419 - 424

PubMed ID

  • 12932730

Pubmed Central ID

  • 12932730

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/S0968-0004(03)00142-7


  • eng

Conference Location

  • England