Human immunodeficiency virus type 1 rev protein as a negative trans-regulator.

Journal Article (Journal Article)

Even though the rev gene of the human immunodeficiency virus type 1 (HIV-1) is essential for viral replication, high levels of rev also downregulate viral gene expression. As the degree of rev protein expression exceeds expression of wild-type virus, a gradient of decreasing viral mRNA synthesis becomes evident. The target sequence for this downregulation resides outside of trans-activating region (TAR) and upstream from the enhancer sequences in the long terminal repeat (LTR), suggesting that regulation is at a transcriptional level.

Full Text

Duke Authors

Cited Authors

  • Sadaie, MR; Benaissa, ZN; Cullen, BR; Wong-Staal, F

Published Date

  • November 1989

Published In

Volume / Issue

  • 8 / 9

Start / End Page

  • 669 - 674

PubMed ID

  • 2693023

International Standard Serial Number (ISSN)

  • 0198-0238

Digital Object Identifier (DOI)

  • 10.1089/dna.1.1989.8.669


  • eng

Conference Location

  • United States