The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators.


Journal Article (Review)

Complex retroviruses, including Human Immunodeficiency Virus Type 1 (HIV-1), are characterized by the ordered temporal expression of the various viral gene products in infected cells. This effect is mediated by a novel class of RNA-sequence-specific regulatory proteins typified by the Rev trans-activator of HIV-1. Evidence suggests that Rev regulates HIV-1 gene expression by intervening in the normal pathway of eukaryotic mRNA processing and transport.

Full Text

Duke Authors

Cited Authors

  • Cullen, BR; Malim, MH

Published Date

  • September 1, 1991

Published In

Volume / Issue

  • 16 / 9

Start / End Page

  • 346 - 350

PubMed ID

  • 1949157

Pubmed Central ID

  • 1949157

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/0968-0004(91)90141-h


  • eng

Conference Location

  • England