Subcellular localization of the human immunodeficiency virus trans-acting art gene product.

Journal Article (Journal Article)

The genome of the human immunodeficiency virus is distinguished from other animal retroviruses by the presence of several additional open reading frames. The protein product of one of these novel genes, which has been termed art or trs, is required for the expression of the virus structural genes but not for the expression of virus encoded regulatory proteins. Immunocytochemistry and subcellular fractionation demonstrate that the art protein is located predominantly in the nucleus. Therefore, any proposed mechanism for the function of art is likely to involve nuclear events.

Full Text

Duke Authors

Cited Authors

  • Cullen, BR; Hauber, J; Campbell, K; Sodroski, JG; Haseltine, WA; Rosen, CA

Published Date

  • July 1988

Published In

Volume / Issue

  • 62 / 7

Start / End Page

  • 2498 - 2501

PubMed ID

  • 2836628

Pubmed Central ID

  • PMC253409

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.62.7.2498-2501.1988


  • eng

Conference Location

  • United States