Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.
Journal Article (Journal Article)
The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.
Full Text
Duke Authors
Cited Authors
- Cullen, BR; Lomedico, PT; Ju, G
Published Date
- January 19, 1984
Published In
Volume / Issue
- 307 / 5948
Start / End Page
- 241 - 245
PubMed ID
- 6363938
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/307241a0
Language
- eng
Conference Location
- England