Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.

Journal Article

The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.

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Duke Authors

Cullen, Bryan R.

Cited Authors

Cullen, BR; Lomedico, PT; Ju, G

Published Date

January 19, 1984

Published In

Nature

Volume / Issue

307 / 5948

Start / End Page

241 - 245

PubMed ID

6363938

International Standard Serial Number (ISSN)

0028-0836

Language

Conference Location

England