Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.

Journal Article (Journal Article)

The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.

Full Text

Duke Authors

Cited Authors

  • Cullen, BR; Lomedico, PT; Ju, G

Published Date

  • January 19, 1984

Published In

Volume / Issue

  • 307 / 5948

Start / End Page

  • 241 - 245

PubMed ID

  • 6363938

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/307241a0


  • eng

Conference Location

  • England