Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA.

Journal Article (Journal Article)

The cDNA corresponding to 4.18 kilobases (kb) of the mRNA of chicken liver fatty acid synthase has been cloned and sequenced. The cDNA corresponds to the 3' end of the mRNA and consists of a 1.87-kb noncoding tail and a 2.31-kb region encoding 769 amino acids of the C terminus of the enzyme. The thioesterase at the C terminus, preceded by the acyl carrier protein, can be identified from known amino acid sequences. However, the identity of the enzymes N terminal to the acyl carrier protein could not be ascertained. The partial amino acid sequence of the chicken liver fatty acid synthase shows greater than 70% similarity with the rat mammary gland enzyme.

Full Text

Duke Authors

Cited Authors

  • Yuan, ZY; Liu, W; Hammes, GG

Published Date

  • September 1988

Published In

Volume / Issue

  • 85 / 17

Start / End Page

  • 6328 - 6331

PubMed ID

  • 2842766

Pubmed Central ID

  • PMC281963

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.85.17.6328


  • eng

Conference Location

  • United States