Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis.
Publication
, Journal Article
Hammes, GG
Published in: Proc Natl Acad Sci U S A
November 1982
A mechanism is proposed for the coupling between ion transport and enzyme catalysis. The basic concept is that enzymes associated with transport exist in two possible conformations. Each conformation has the potential of catalyzing the enzymatic reaction, and pumping is associated with the conversion of one conformational form to the other. The conformational transition is triggered by the kinetic blockage of specific mechanistic steps for each conformation. Such blockages can cause a cycling between the two conformations concomitant with catalysis. This mechanistic concept is consistent with a variety of results obtained with the Na+,K+-ATPase, the Ca2+,Mg2+-ATPase, and ATP synthesizing enzymes (coupling factors).
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 1982
Volume
79
Issue
22
Start / End Page
6881 / 6884
Location
United States
Related Subject Headings
- Sodium-Potassium-Exchanging ATPase
- Phosphotransferases
- Multienzyme Complexes
- Kinetics
- Hydrolysis
- Calcium-Transporting ATPases
- Ca(2+) Mg(2+)-ATPase
- Biological Transport, Active
- Animals
- Adenosine Triphosphate
Citation
APA
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ICMJE
MLA
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Hammes, G. G. (1982). Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. Proc Natl Acad Sci U S A, 79(22), 6881–6884. https://doi.org/10.1073/pnas.79.22.6881
Hammes, G. G. “Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis.” Proc Natl Acad Sci U S A 79, no. 22 (November 1982): 6881–84. https://doi.org/10.1073/pnas.79.22.6881.
Hammes GG. Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. Proc Natl Acad Sci U S A. 1982 Nov;79(22):6881–4.
Hammes, G. G. “Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis.” Proc Natl Acad Sci U S A, vol. 79, no. 22, Nov. 1982, pp. 6881–84. Pubmed, doi:10.1073/pnas.79.22.6881.
Hammes GG. Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. Proc Natl Acad Sci U S A. 1982 Nov;79(22):6881–6884.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 1982
Volume
79
Issue
22
Start / End Page
6881 / 6884
Location
United States
Related Subject Headings
- Sodium-Potassium-Exchanging ATPase
- Phosphotransferases
- Multienzyme Complexes
- Kinetics
- Hydrolysis
- Calcium-Transporting ATPases
- Ca(2+) Mg(2+)-ATPase
- Biological Transport, Active
- Animals
- Adenosine Triphosphate