The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.
Publication
, Journal Article
Kadowaki, T; Wilder, E; Klingensmith, J; Zachary, K; Perrimon, N
Published in: Genes Dev
December 15, 1996
The Wnt protein Wingless (Wg) functions as a signal in patterning of both the Drosophila embryo and imaginal discs. Lack of porcupine (porc) activity is associated with mutant phenotypes similar to those of wg mutations. In porc mutant embryos, Wg protein is confined to the cells that produce it, suggesting that Porc plays a role in processing or secretion of Wg. porc encodes a novel transmembrane protein that appears to be concentrated at the endoplasmic reticulum. We present both genetic and in vitro evidence demonstrating that porc is involved specifically in the processing of Wg. We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts.
Duke Scholars
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Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
December 15, 1996
Volume
10
Issue
24
Start / End Page
3116 / 3128
Location
United States
Related Subject Headings
- Wnt1 Protein
- Wings, Animal
- Solubility
- Sequence Alignment
- Proto-Oncogene Proteins
- Proteins
- Protein Processing, Post-Translational
- Polymorphism, Restriction Fragment Length
- Molecular Sequence Data
- Membrane Proteins
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Kadowaki, T., Wilder, E., Klingensmith, J., Zachary, K., & Perrimon, N. (1996). The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev, 10(24), 3116–3128. https://doi.org/10.1101/gad.10.24.3116
Kadowaki, T., E. Wilder, J. Klingensmith, K. Zachary, and N. Perrimon. “The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.” Genes Dev 10, no. 24 (December 15, 1996): 3116–28. https://doi.org/10.1101/gad.10.24.3116.
Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996 Dec 15;10(24):3116–28.
Kadowaki, T., et al. “The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.” Genes Dev, vol. 10, no. 24, Dec. 1996, pp. 3116–28. Pubmed, doi:10.1101/gad.10.24.3116.
Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996 Dec 15;10(24):3116–3128.
Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
December 15, 1996
Volume
10
Issue
24
Start / End Page
3116 / 3128
Location
United States
Related Subject Headings
- Wnt1 Protein
- Wings, Animal
- Solubility
- Sequence Alignment
- Proto-Oncogene Proteins
- Proteins
- Protein Processing, Post-Translational
- Polymorphism, Restriction Fragment Length
- Molecular Sequence Data
- Membrane Proteins