A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.

Journal Article

We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.

Full Text

Duke Authors

Cited Authors

  • Yin, JC; Wallach, JS; Wilder, EL; Klingensmith, J; Dang, D; Perrimon, N; Zhou, H; Tully, T; Quinn, WG

Published Date

  • September 1995

Published In

Volume / Issue

  • 15 / 9

Start / End Page

  • 5123 - 5130

PubMed ID

  • 7651429

International Standard Serial Number (ISSN)

  • 0270-7306

Language

  • eng

Conference Location

  • United States