A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.
Publication
, Journal Article
Yin, JC; Wallach, JS; Wilder, EL; Klingensmith, J; Dang, D; Perrimon, N; Zhou, H; Tully, T; Quinn, WG
Published in: Mol Cell Biol
September 1995
We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.
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Published In
Mol Cell Biol
DOI
ISSN
0270-7306
Publication Date
September 1995
Volume
15
Issue
9
Start / End Page
5123 / 5130
Location
United States
Related Subject Headings
- Transcription, Genetic
- Trans-Activators
- Tissue Distribution
- Sequence Homology, Amino Acid
- Repressor Proteins
- Protein Binding
- Molecular Sequence Data
- In Situ Hybridization
- Head
- Genes, Insect
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Yin, J. C., Wallach, J. S., Wilder, E. L., Klingensmith, J., Dang, D., Perrimon, N., … Quinn, W. G. (1995). A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Mol Cell Biol, 15(9), 5123–5130. https://doi.org/10.1128/MCB.15.9.5123
Yin, J. C., J. S. Wallach, E. L. Wilder, J. Klingensmith, D. Dang, N. Perrimon, H. Zhou, T. Tully, and W. G. Quinn. “A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.” Mol Cell Biol 15, no. 9 (September 1995): 5123–30. https://doi.org/10.1128/MCB.15.9.5123.
Yin JC, Wallach JS, Wilder EL, Klingensmith J, Dang D, Perrimon N, et al. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Mol Cell Biol. 1995 Sep;15(9):5123–30.
Yin, J. C., et al. “A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.” Mol Cell Biol, vol. 15, no. 9, Sept. 1995, pp. 5123–30. Pubmed, doi:10.1128/MCB.15.9.5123.
Yin JC, Wallach JS, Wilder EL, Klingensmith J, Dang D, Perrimon N, Zhou H, Tully T, Quinn WG. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Mol Cell Biol. 1995 Sep;15(9):5123–5130.
Published In
Mol Cell Biol
DOI
ISSN
0270-7306
Publication Date
September 1995
Volume
15
Issue
9
Start / End Page
5123 / 5130
Location
United States
Related Subject Headings
- Transcription, Genetic
- Trans-Activators
- Tissue Distribution
- Sequence Homology, Amino Acid
- Repressor Proteins
- Protein Binding
- Molecular Sequence Data
- In Situ Hybridization
- Head
- Genes, Insect