Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.


Journal Article

PURPOSE: We report a case of infection-associated hemophagocytic syndrome in the setting of disseminated histoplasmosis. PATIENTS AND METHODS: A 6-year-old boy with chronic mucocutaneous candidiasis developed a fulminant hemophagocytic syndrome. Evaluation for an infectious cause included bacterial, mycobacterial, viral, and fungal cultures, serological assessment, and histological examination of bone marrow and bronchoalveolar lavage fluid. RESULTS: Culture of bone marrow aspirate, blood, and bronchoalveolar lavage showed disseminated histoplasmosis as the cause for this patient's hemophagocytic syndrome. The patient was treated with amphotericin B with complete resolution of his hemophagocytic syndrome. CONCLUSIONS: Disseminated histoplasmosis is another cause of IAHS in children with an underlying immunodeficiency. Diagnostic difficulties associated with the hemophagocytic syndromes of childhood are discussed.

Full Text

Duke Authors

Cited Authors

  • Keller, FG; Kurtzberg, J

Published Date

  • November 1994

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 368 - 371

PubMed ID

  • 7978059

Pubmed Central ID

  • 7978059

International Standard Serial Number (ISSN)

  • 0192-8562


  • eng

Conference Location

  • United States