Cisplatinum-induced renal salt wasting.


Journal Article

We report two patients who developed high urinary excretion of sodium chloride after receiving cisplatinum. One patient became symptomatically hyponatremic during intravenous administration of hypotonic fluid. The second patient developed orthostatic hypotension. Urine sodium and chloride concentrations exceeded 130 mmol/liter despite hyponatremia or volume depletion. There was no evidence of adrenal cortical impairment and no improvement with fludrocortisone. We propose that cisplatinum may inhibit solute transport by the thick ascending limb of Henle, causing clinically significant, previously unreported toxicity in patients receiving chronic cisplatinum antitumor therapy.

Full Text

Duke Authors

Cited Authors

  • Kurtzberg, J; Dennis, VW; Kinney, TR

Published Date

  • 1984

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 150 - 154

PubMed ID

  • 6538257

Pubmed Central ID

  • 6538257

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950120219


  • eng

Conference Location

  • United States