Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.


Journal Article

We have studied the in vitro effects of carbovir as compared to 3'-azido-3'-deoxythymidine (AZT) on the growth of clonal bone marrow-derived hematopoietic progenitor cells. (-)Carbovir, the enantiomer with anti-human immunodeficiency virus (HIV) activity, exhibited significantly less toxicity to hematopoietic cells than AZT. These in vitro studies suggest that (-)carbovir will exhibit less hematologic toxicity in the therapy of patients infected with HIV either as a single agent or in combination with other agents that inhibit HIV proliferation.

Full Text

Duke Authors

Cited Authors

  • Kurtzberg, J; Carter, SG

Published Date

  • November 1990

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 1094 - 1096

PubMed ID

  • 2209763

Pubmed Central ID

  • 2209763

International Standard Serial Number (ISSN)

  • 0301-472X


  • eng

Conference Location

  • Netherlands