Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.

Journal Article (Journal Article)

We have studied the in vitro effects of carbovir as compared to 3'-azido-3'-deoxythymidine (AZT) on the growth of clonal bone marrow-derived hematopoietic progenitor cells. (-)Carbovir, the enantiomer with anti-human immunodeficiency virus (HIV) activity, exhibited significantly less toxicity to hematopoietic cells than AZT. These in vitro studies suggest that (-)carbovir will exhibit less hematologic toxicity in the therapy of patients infected with HIV either as a single agent or in combination with other agents that inhibit HIV proliferation.

Full Text

Duke Authors

Cited Authors

  • Kurtzberg, J; Carter, SG

Published Date

  • November 1990

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 1094 - 1096

PubMed ID

  • 2209763

International Standard Serial Number (ISSN)

  • 0301-472X


  • eng

Conference Location

  • Netherlands