Loss of autoreceptor functions in mice lacking the dopamine transporter.

Published

Journal Article

Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a component of several neuropsychiatric disorders. However, evidence concerning the state of autoreceptors in such conditions has remained elusive. The function of dopamine autoreceptors was assessed in mice lacking the dopamine transporter (DAT). Genetic deletion of the DAT gene in mice results in a persistent elevation in levels of extracellular dopamine. Direct assessment of impulse-, synthesis- and release-regulating autoreceptors in these mice reveals a nearly complete loss of function. These findings may provide insight into the neurochemical consequences of hyperdopaminergia.

Full Text

Duke Authors

Cited Authors

  • Jones, SR; Gainetdinov, RR; Hu, XT; Cooper, DC; Wightman, RM; White, FJ; Caron, MG

Published Date

  • July 1999

Published In

Volume / Issue

  • 2 / 7

Start / End Page

  • 649 - 655

PubMed ID

  • 10404198

Pubmed Central ID

  • 10404198

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/10204

Language

  • eng

Conference Location

  • United States