Stereoisomers of the atypical neuroleptic carbidine modulate striatal dopamine release in awake rats.


Journal Article

Intracerebral microdialysis was used to monitor extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid and homovanillic acid in awake rats, after intraperitoneal administration of the cis- and trans-isomers (25 mg/kg and 1 mg/kg, respectively) of carbidine, the atypical neuroleptic drug, in comparison with sulpiride (50 mg/kg) and haloperidol (1 mg/kg). Trans-carbidine was found to be more potent than the cis-isomer in increasing the release of DA. In contrast to sulpiride and haloperidol, both isomers at the doses used, produced only a moderate elevation in the levels of the metabolites of DA. Transcarbidine seemed to be more potent as a neuroleptic drug, in comparison with the cis-isomer.

Full Text

Duke Authors

Cited Authors

  • Guinetdinov, RR; Bogdanov, MB; Pogorelov, VM; Kudrin, VS; Rayevsky, KS

Published Date

  • November 1991

Published In

Volume / Issue

  • 30 / 11

Start / End Page

  • 1251 - 1254

PubMed ID

  • 1685561

Pubmed Central ID

  • 1685561

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/0028-3908(91)90173-9


  • eng

Conference Location

  • England