[Study by the intracerebral microdialysis method of the effects of atypical neuroleptics and anxiolytics on striatal release and metabolism of dopamine in awake rats].


Journal Article

Using brain microdialysis in awake rats effects of risperidone, ritanserin, buspirone, sulpiride and 5-methoxy-N,N-dimethyltryptamine (MeODMT) on striatal dopamine (DA) release and metabolism were studied. Risperidone, sulpiride and buspirone increased levels of DA, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). Ritanserin failed to affect DA release, while increased DOPAC and HVA levels. MeODMT had no effect on striatal DA release and metabolism. Possible interaction between DA and serotonin systems is discussed.

Full Text

Cited Authors

  • Bogdanov, MB; Gań≠netdinov, RR; Kudrin, VS; Medvedev, OS; Val'dman, AV

Published Date

  • May 1991

Published In

Volume / Issue

  • 111 / 5

Start / End Page

  • 505 - 507

PubMed ID

  • 1715214

Pubmed Central ID

  • 1715214

International Standard Serial Number (ISSN)

  • 0365-9615


  • rus

Conference Location

  • Russia (Federation)