Genetic animal models: focus on schizophrenia.


Journal Article (Review)

The neurobiology of schizophrenia remains poorly understood. Symptoms of schizophrenia are classically thought to be associated with an imbalance of the dopaminergic system. However, the contribution of other neurotransmitters, in particular glutamate, has been increasingly appreciated. The role of individual components of neurotransmitter systems in aberrant behaviors can be experimentally tested in transgenic animals. Dopamine transporter knockout mice display persistently elevated dopaminergic tone and therefore might be appropriate substrates to evaluate the dopamine hypothesis. Similarly, NMDA receptor-deficient mice can be used to evaluate the glutamate hypothesis of schizophrenia. In this review we discuss how such animal models might be relevant for understanding the neurochemical underpinnings of certain manifestations of schizophrenia.

Full Text

Duke Authors

Cited Authors

  • Gainetdinov, RR; Mohn, AR; Caron, MG

Published Date

  • September 2001

Published In

Volume / Issue

  • 24 / 9

Start / End Page

  • 527 - 533

PubMed ID

  • 11506886

Pubmed Central ID

  • 11506886

International Standard Serial Number (ISSN)

  • 0166-2236


  • eng

Conference Location

  • England