Dopamine transporters and neuronal injury.

Published

Journal Article (Review)

The plasma membrane dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) are essential for normal dopamine neurotransmission. DAT terminates the actions of dopamine by rapidly removing dopamine from the synapse, whereas VMAT2 loads cytoplasmic dopamine into vesicles for storage and subsequent release. Recent data suggest that perturbation of the tightly regulated balance between these two transporters predisposes the neurone to damage by a variety of insults. Most notable is the selective degeneration of DAT- and VMAT2-expressing dopamine nerve terminals in the striatum thought to underlie Parkinson's disease. DAT and VMAT2 expression can predict the selective vulnerability of neuronal populations, which suggests that therapeutic strategies aimed at altering DAT and VMAT2 function could have significant benefits in a variety of disorders.

Full Text

Duke Authors

Cited Authors

  • Miller, GW; Gainetdinov, RR; Levey, AI; Caron, MG

Published Date

  • October 1999

Published In

Volume / Issue

  • 20 / 10

Start / End Page

  • 424 - 429

PubMed ID

  • 10498956

Pubmed Central ID

  • 10498956

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/s0165-6147(99)01379-6

Language

  • eng

Conference Location

  • England