[A comparative study of the neurochemical profiles of carbidine stereoisomers].


Journal Article

The effects of cis- and trans-isomers of atypical neuroleptic carbidine on the synthesis of dopamine and its autoreceptor regulation in the striatum and nucleus accumbens of rats were examined by blocking decarboxylase of L-aromatic amino acids and interrupting the nerve impulse flow in the dopaminergic neurons. The striatal release and metabolism of dopamine were studied in vitro by employing K(+)-stimulated efflux from isolated striata and in vivo by the microdialysis in freely moving rats. Carbidine trans-isomer, unlike its cis-isomer, was shown to enhance the biosynthesis of dopamine via blockade of presynaptic autoreceptors presumably located on the dopaminergic terminals. The trans-isomer was found to be much more potent by affecting the neurochemical parameters of dopaminergic neurotransmission, which are essential for the drug to produce its antipsychotic effect.

Full Text

Duke Authors

Cited Authors

  • Gaĭnetdinov, RR; Miroshnichenko, II; Kudrin, VS; Bogdanov, MB; Pogorelov, VM; Budygin, EA; Kovalev, GI; Raevskiĭ, KS

Published Date

  • January 1, 1993

Published In

Volume / Issue

  • 56 / 1

Start / End Page

  • 24 - 27

PubMed ID

  • 8100728

Pubmed Central ID

  • 8100728

International Standard Serial Number (ISSN)

  • 0869-2092


  • rus

Conference Location

  • Russia (Federation)