Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene.


Journal Article (Review)

Norepinephrine is an important chemical messenger in the nervous system. It regulates affective states, learning and memory, endocrine and autonomic functions. It has been implicated in depression, aggression, and addiction, as well as cardiac and thermal dysregulation. The norepinephrine transporter functions by uptaking norepinephrine back into the cell for cyclic use, and is a direct target of a number of antidepressants and psychostimulants. Functional deletion (knockout) of monamine transporters results in increases in extracellular levels of neurotransmitters, thereby prolonging their actions. For the norepinephrine transporter knockout mice, this altered state of the norepinephrine system should simulate the therapeutic effects of norepinephrine selective antidepressants and some of the effects of psychostimulants. Careful use of such an animal model can hopefully provide valuable insight into the multiple roles norepinephrine plays in normal and pathological physiology.

Full Text

Duke Authors

Cited Authors

  • Wang, YM; Xu, F; Gainetdinov, RR; Caron, MG

Published Date

  • November 1, 1999

Published In

Volume / Issue

  • 46 / 9

Start / End Page

  • 1124 - 1130

PubMed ID

  • 10560019

Pubmed Central ID

  • 10560019

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(99)00245-0


  • eng

Conference Location

  • United States