Correlation between behavior and extracellular dopamine levels in rat striatum: comparison of microdialysis and fast-scan cyclic voltammetry.


Journal Article

Recently, fast-scan cyclic voltammetry (FSCV) has been adapted for real-time measurements of evoked dopamine (DA) release and uptake in freely moving rats. Using the advantages of this experimental design in combination with behavioral measures, we examined the effect of GBR 12909 (20 mg/kg, i.p.), a selective DA uptake inhibitor, on striatal extracellular DA dynamics and compared these data to that obtained by microdialysis. These studies established that both techniques report changes in DA that correlate with the kinetics of GBR 12909-induced behavioral effects. However, the time course of changes in evoked DA levels detected by FSCV was more closely linked with the changes in stereotypy than microdialysis measurements.

Full Text

Duke Authors

Cited Authors

  • Budygin, EA; Kilpatrick, MR; Gainetdinov, RR; Wightman, RM

Published Date

  • March 3, 2000

Published In

Volume / Issue

  • 281 / 1

Start / End Page

  • 9 - 12

PubMed ID

  • 10686403

Pubmed Central ID

  • 10686403

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(00)00813-2


  • eng

Conference Location

  • Ireland