Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice.


Journal Article

Acetylcholine serves an important modulatory role in the central nervous system. Pharmacological evidence has suggested that cholinergic activity can modulate central dopaminergic transmission; however, the nature of this interaction and the receptors involved remain undefined. In this study we have generated mice lacking the M1 muscarinic acetylcholine receptor and examined the effects of M1 deletion on dopaminergic transmission and locomotor behavior. We report that M1 deficiency leads to elevated dopaminergic transmission in the striatum and significantly increased locomotor activity. M1-deficient mice also have an increased response to the stimulatory effects of amphetamine. Our results provide direct evidence for regulation of dopaminergic transmission by the M1 receptor and are consistent with the idea that M1 dysfunction could be a contributing factor in psychiatric disorders in which altered dopaminergic transmission has been implicated.

Full Text

Duke Authors

Cited Authors

  • Gerber, DJ; Sotnikova, TD; Gainetdinov, RR; Huang, SY; Caron, MG; Tonegawa, S

Published Date

  • December 18, 2001

Published In

Volume / Issue

  • 98 / 26

Start / End Page

  • 15312 - 15317

PubMed ID

  • 11752469

Pubmed Central ID

  • 11752469

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.261583798


  • eng

Conference Location

  • United States