[Effects of haloperidol on extracellular contents of dopamine and its metabolites in the septum of rats during interspecies aggression].


Journal Article

The extracellular levels of dopamine (DA) and its metabolites in the septum of freely moving rats were studied using "push-pull" method during muricidal aggression before and after haloperidol (2 mg/kg, i. p.) treatment. Mouse-killing activity of the rats was accompanied by significant reduction of the output of DA and metabolites in this brain area. Haloperidol suppressed muricidal activity of the rats and increased the extracellular levels of DA metabolites. In contrast, the decrease of DA release monitoring during killing activity was not affected by haloperidol administration. Possible role of the septal dopaminergic mechanisms underlying muricidal behaviour and the drug effects is discussed.

Full Text

Duke Authors

Cited Authors

  • Gań≠netdinov, RR; Gromov, AI; Kudrin, VS; Pletnikov, MS

Published Date

  • September 1992

Published In

Volume / Issue

  • 114 / 9

Start / End Page

  • 231 - 233

PubMed ID

  • 1477338

Pubmed Central ID

  • 1477338

International Standard Serial Number (ISSN)

  • 0365-9615


  • rus

Conference Location

  • Russia (Federation)