[A comparative study of the neurochemical profiles of remoxipride, raclopride and metoclopramide activity].


Journal Article

Effects of intraperitoneal administration of remoxipride (2.4 mg/kg), raclopride (1.2 mg/kg) and metoclopramide (5 mg/kg) on the concentration of monoamines and metabolites in various brain regions, on the DA and serotonin biosynthesis in the striatum and nucleus accumbens, on the K(+)-stimulated DA release from the isolated striatum, on the extracellular levels of DA and metabolites in the striatum of freely moving rats were studied. Remoxipride and raclopride increase DA turnover, biosynthesis and DA release, studied both in vitro and in vivo. Metoclopramide was shown to be more effective in increasing DA turnover and biosynthesis, while exerted less activity in regard to increasing DA release in vivo and failed to affect release in vitro. Possible neurochemical mechanisms underlying pharmacological effects of these drugs are discussed.

Full Text

Duke Authors

Cited Authors

  • Gaĭnetdinov, RR; Bogdanov, MB; Kudrin, VS; Budygin, EA; Kovalev, GI; Raevskiĭ, KS

Published Date

  • July 1992

Published In

Volume / Issue

  • 114 / 8

Start / End Page

  • 165 - 168

PubMed ID

  • 1467481

Pubmed Central ID

  • 1467481

International Standard Serial Number (ISSN)

  • 0365-9615


  • rus

Conference Location

  • Russia (Federation)