Functional hyperdopaminergia in dopamine transporter knock-out mice.

Journal Article (Journal Article;Review)

Dopamine is an important regulator of many central nervous system functions. Hyperfunction of the dopaminergic system is believed to be related to several pathological conditions. Genetic deletion of the dopamine transporter gene in mice results in a persistent extracellular hyperdopaminergic tone, that is functionally revealed as hyperactivity. The lack of a reuptake mechanism produces a marked increase in functional extracellular dopamine which results in profound plasticity of pre- and postsynaptic parameters of dopamine homeostasis. The mice lacking the dopamine transporter gene may represent an appropriate model to elucidate the molecular adaptive changes accompanying pathological states associated with hyperdopaminergic function.

Full Text

Duke Authors

Cited Authors

  • Gainetdinov, RR; Jones, SR; Caron, MG

Published Date

  • August 1, 1999

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 303 - 311

PubMed ID

  • 10435196

Pubmed Central ID

  • 10435196

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/s0006-3223(99)00122-5


  • eng

Conference Location

  • United States