[The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups].


Journal Article

The influence of prenatal exposure to ethanol on endogenous Dopamine (DA) release from perfused isolated striata of 20-day-old rats was studied, as well as its correction by nootropic drugs: sodium hydroxy butyrate and nooglutil. Administration of 20% ethanol per os at a daily dose of 5 mg per kg during the entire period of pregnancy led to a significant decrease in basal and K(+)-evoked DA efflux. Hydroxy-butyrate and Nooglutil (50 and 25 mg per kg, subcutaneously, daily from the 8th to the 20th day of life) normalized these alterations in alcohol-exposed neonates, although their effects on the offsprings of non-alcoholized rats were opposite. The probable neurochemical targets of ethanol and nootropics are discussed.

Full Text

Duke Authors

Cited Authors

  • Kovalev, GI; Budygin, EA; Gań≠netdinov, RR; Kudrin, VS; Trofimov, SS; Ostrovskaia, RU

Published Date

  • July 1993

Published In

Volume / Issue

  • 116 / 7

Start / End Page

  • 56 - 58

PubMed ID

  • 8400184

Pubmed Central ID

  • 8400184

International Standard Serial Number (ISSN)

  • 0365-9615


  • rus