[Selective analyzers of dopamine D2 receptors modulate serotonin metabolism in the striatum and nucleus accumbens of the rat brain during blockade of dopaminergic impulse flow]


Journal Article

Effects of D2 dopamine receptor selective agonists: quinpirole (0.1, 0.3 and 1 mg/kg, i. p.), pergolide (0.3 mg/kg, i. p.), lisuride (0.1 mg/kg, i. p.) and antagonist raclopride (1.2 mg/kg, i. p.) on the metabolism and synthesis of DA and serotonin in the rat brain striatum and nucleus accumbens after GBL treatment were studied. GBL as well as dopamine D2 receptor selective drugs were shown not only to change neurochemical parameters of dopaminergic brain systems, but also to modulate serotonin metabolism without affecting its biosynthesis.

Full Text

Duke Authors

Cited Authors

  • Gaĭnetdinov, RR; Bogdanov, MB; Kudrin, VS; Raevskiĭ, KS

Published Date

  • June 1992

Published In

Volume / Issue

  • 113 / 6

Start / End Page

  • 614 - 616

PubMed ID

  • 1359911

Pubmed Central ID

  • 1359911

International Standard Serial Number (ISSN)

  • 0365-9615


  • rus