[The effect of the dopamine neuronal reuptake inhibitor GBR 12909 on the dopaminergic neurotransmission parameters in the rat striatum in vivo].

Journal Article

The aim of the present research was to investigate the effects of the selective dopamine re-uptake inhibitor GBR 12909 (10 mg/kg, i.p.) on dopaminergic neurotransmission in rat striatum. GBR 12909 increased DA levels in microdialysis samples from freely moving rats. In contrast, administration of GBR 12909 slightly decreased the NSD 1015 (50 mg/kg)--induced DOPA accumulation. This result may be explained as a decrease in DA biosynthesis in response to an increasing amount of DA in the synaptic cleft. Fast-scan cyclic voltammetric monitoring of electrically-evoked DA showed significant changes after the drug in DA re-uptake (Km), but not DA release. In conclusion, our results support the notion, that GBR 12909 is a specific DA uptake inhibitor without any transmitter releasing action.

Full Text

Duke Authors

Cited Authors

  • Budygin, EA; Kilpatrick, M; Gaĭnetdinov, RR; Raevskiĭ, KS; Wightman, RM

Published Date

  • September 1999

Published In

Volume / Issue

  • 62 / 5

Start / End Page

  • 3 - 6

PubMed ID

  • 10572741

International Standard Serial Number (ISSN)

  • 0869-2092

Language

  • rus

Conference Location

  • Russia (Federation)