[The nooglutil correction of functional disorders of the central nervous system caused by prenatal alcoholization in rats].


Journal Article

Administration of ethanol (5 g/kg/day, per os) to the pregnant rats evoked delayed impairments of the learning and memory in the offspring. Prenatal alcoholization of the animals attenuated the habituation of the exploration behavior in open field, impaired acquisition and retention of active avoidance in a shuttle box, increased slow activity of the EEG spectrum power, disturbed the function of the serotoninergic system in the brain cortex and of the dopaminergic system in the hippocamp. The new nootropic drug nooglutyl (N-5/hydroxynicotinoyl/-L-glutamic acid) administered in a dose of 25 mg/kg/day from the 8th to the 20th day of life prevented the above-mentioned delayed disturbances of higher integrative functions and biochemical processes in rat brain.

Full Text

Duke Authors

Cited Authors

  • Trofimov, SS; Ostrovskaia, RU; Smol'nikova, NM; Khromova, IV; Krapivin, SV; Krylova, AM; Kovalev, GI; Gań≠netdinov, RR; Liubimov, BI; Voronina, TA

Published Date

  • January 1, 1992

Published In

Volume / Issue

  • 55 / 1

Start / End Page

  • 18 - 21

PubMed ID

  • 1305426

Pubmed Central ID

  • 1305426

International Standard Serial Number (ISSN)

  • 0869-2092


  • rus