Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia.

Journal Article

Calcineurin (CN), a calcium- and calmodulin-dependent protein phosphatase, plays a significant role in the central nervous system. Previously, we reported that forebrain-specific CN knockout mice (CN mutant mice) have impaired working memory. To further analyze the behavioral effects of CN deficiency, we subjected CN mutant mice to a comprehensive behavioral test battery. Mutant mice showed increased locomotor activity, decreased social interaction, and impairments in prepulse inhibition and latent inhibition. In addition, CN mutant mice displayed an increased response to the locomotor stimulating effects of MK-801. Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Miyakawa, T; Leiter, LM; Gerber, DJ; Gainetdinov, RR; Sotnikova, TD; Zeng, H; Caron, MG; Tonegawa, S

Published Date

  • July 22, 2003

Published In

Volume / Issue

  • 100 / 15

Start / End Page

  • 8987 - 8992

PubMed ID

  • 12851457

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1432926100

Language

  • eng

Conference Location

  • United States