Matrix‐assisted laser desorption/ionization mass spectrometry of synthetic oligodeoxyribonucleotides


Journal Article

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry has been used to mass analyze a variety of synthetic oligodeoxyribonucleotides ranging in size from 6 to 30 nucleotides. Molecular ions were observed almost exclusively, with little or no fragmentation and generally minor contributions from multiply charged species. Mixtures of poly d(T)12–30 with low picomole amounts of each component gave well resolved peaks. These results are encouraging for the concept of DNA sequence analysis by mass spectrometry. Copyright © 1992 John Wiley & Sons, Ltd.

Full Text

Duke Authors

Cited Authors

  • Parr, GR; Fitzgerald, MC; Smith, LM

Published Date

  • January 1, 1992

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 369 - 372

Electronic International Standard Serial Number (EISSN)

  • 1097-0231

International Standard Serial Number (ISSN)

  • 0951-4198

Digital Object Identifier (DOI)

  • 10.1002/rcm.1290060603

Citation Source

  • Scopus