Direct monitoring of organic reactions on polymeric supports

Journal Article (Journal Article)

A method to use matrix-assisted laser desorption/ionization mass spectrometry MALDI-MS) for real time monitoring of organic reactions on polymeric supports used in solid-phase synthesis is described. The strategy utilizes a synthetic construct that allows for the rapid and convenient direct MALDI analysis of the attached substrates as well as their subsequent chemical cleavage as desired. We have used this strategy to monitor nucleophilic substitutions, palladium-catalyzed coupling reactions, and solid phase peptide synthesis reactions using both Boc- and Fmoc-based chemistries.

Full Text

Duke Authors

Cited Authors

  • Carrasco, MR; Fitzgerald, MC; Oda, Y; Kent, SBH

Published Date

  • September 8, 1997

Published In

Volume / Issue

  • 38 / 36

Start / End Page

  • 6331 - 6334

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(97)01456-1

Citation Source

  • Scopus