Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis.
Publication
, Journal Article
Ulshen, MH; Grand, RJ; Crain, JD; Gelfand, EW
Published in: J Pediatr
December 1978
Encephalopathy secondary to aspirin-induced hepatoxicity developed in three patients with JRA. In each patient clinical and biochemical resolution occurred after discontinuing the drug, but toxicity appeared on rechallenge. Liver biopsies in two patients showed mild nonspecific changes. Acute hepatic decompensation and encephalopathy may occur as a consequence of aspirin hepatoxicity in JRA and justify sequential observations of liver function tests and salicylate levels in such patients.
Duke Scholars
Published In
J Pediatr
DOI
ISSN
0022-3476
Publication Date
December 1978
Volume
93
Issue
6
Start / End Page
1034 / 1037
Location
United States
Related Subject Headings
- Pediatrics
- Liver
- Humans
- Child, Preschool
- Child
- Chemical and Drug Induced Liver Injury
- Brain Diseases
- Biopsy
- Aspirin
- Arthritis, Rheumatoid
Citation
APA
Chicago
ICMJE
MLA
NLM
Ulshen, M. H., Grand, R. J., Crain, J. D., & Gelfand, E. W. (1978). Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. J Pediatr, 93(6), 1034–1037. https://doi.org/10.1016/s0022-3476(78)81252-9
Ulshen, M. H., R. J. Grand, J. D. Crain, and E. W. Gelfand. “Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis.” J Pediatr 93, no. 6 (December 1978): 1034–37. https://doi.org/10.1016/s0022-3476(78)81252-9.
Ulshen MH, Grand RJ, Crain JD, Gelfand EW. Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. J Pediatr. 1978 Dec;93(6):1034–7.
Ulshen, M. H., et al. “Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis.” J Pediatr, vol. 93, no. 6, Dec. 1978, pp. 1034–37. Pubmed, doi:10.1016/s0022-3476(78)81252-9.
Ulshen MH, Grand RJ, Crain JD, Gelfand EW. Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. J Pediatr. 1978 Dec;93(6):1034–1037.
Published In
J Pediatr
DOI
ISSN
0022-3476
Publication Date
December 1978
Volume
93
Issue
6
Start / End Page
1034 / 1037
Location
United States
Related Subject Headings
- Pediatrics
- Liver
- Humans
- Child, Preschool
- Child
- Chemical and Drug Induced Liver Injury
- Brain Diseases
- Biopsy
- Aspirin
- Arthritis, Rheumatoid