Microbial hydroxylation and reduction of the diterpene psiadin.

Journal Article (Journal Article)

Microbial bioconversion studies conducted on the diterpene psiadin have revealed that it was metabolized by Aspergillus niger (NRRL 2295) to give 2alpha-hydroxydeoxopsiadin, Cunninghamella blakesleeana (ATCC 8688a) to give 11beta-hydroxypsiadin, and Cylindrocephalum aureum (ATCC 12720), Gongronella butleri (ATCC 22822), Kloeckera africana (ATCC 20111), and Kluyveromyces marxianus var. lactis (ATCC 2628) to yield 7alpha-hydroxypsiadin. Their structures have been established on the basis of spectral data. The structure and relative stereochemistry of 7alpha-hydroxypsiadin was confirmed by single-crystal X-ray analysis.

Full Text

Duke Authors

Cited Authors

  • Orabi, KY; Galal, AM; Ibrahim, AR; El-Feraly, FS; McPhail, AT

Published Date

  • March 2001

Published In

Volume / Issue

  • 56 / 3-4

Start / End Page

  • 216 - 222

PubMed ID

  • 11371011

Electronic International Standard Serial Number (EISSN)

  • 1865-7125

International Standard Serial Number (ISSN)

  • 0939-5075

Digital Object Identifier (DOI)

  • 10.1515/znc-2001-3-408


  • eng