A novel microbial metabolite, activator of low density lipoprotein receptor promoter
Publication
, Journal Article
Hegde, VR; Puar, MS; Dai, P; Patel, M; Gullo, VP; Das, PR; Bond, RW; McPhail, AT
Published in: Tetrahedron Letters
February 26, 2000
The organic extract of the fermentation broth of a Micromonospora microorganism was found to contain SCH 351448 (1), the monosodium salt of a macrocyclic dilactone containing two identical diacids. The structure and relative stereochemistry were established by single-crystal X-ray analysis. SCH 351448 is a novel ionophoric compound and is a weak activator of low density lipoprotein receptor (LDL-R) promoter with an IC50 of 25 μM. (C) 2000 Elsevier Science Ltd.
Duke Scholars
Published In
Tetrahedron Letters
DOI
ISSN
0040-4039
Publication Date
February 26, 2000
Volume
41
Issue
9
Start / End Page
1351 / 1354
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Hegde, V. R., Puar, M. S., Dai, P., Patel, M., Gullo, V. P., Das, P. R., … McPhail, A. T. (2000). A novel microbial metabolite, activator of low density lipoprotein receptor promoter. Tetrahedron Letters, 41(9), 1351–1354. https://doi.org/10.1016/S0040-4039(99)02291-1
Hegde, V. R., M. S. Puar, P. Dai, M. Patel, V. P. Gullo, P. R. Das, R. W. Bond, and A. T. McPhail. “A novel microbial metabolite, activator of low density lipoprotein receptor promoter.” Tetrahedron Letters 41, no. 9 (February 26, 2000): 1351–54. https://doi.org/10.1016/S0040-4039(99)02291-1.
Hegde VR, Puar MS, Dai P, Patel M, Gullo VP, Das PR, et al. A novel microbial metabolite, activator of low density lipoprotein receptor promoter. Tetrahedron Letters. 2000 Feb 26;41(9):1351–4.
Hegde, V. R., et al. “A novel microbial metabolite, activator of low density lipoprotein receptor promoter.” Tetrahedron Letters, vol. 41, no. 9, Feb. 2000, pp. 1351–54. Scopus, doi:10.1016/S0040-4039(99)02291-1.
Hegde VR, Puar MS, Dai P, Patel M, Gullo VP, Das PR, Bond RW, McPhail AT. A novel microbial metabolite, activator of low density lipoprotein receptor promoter. Tetrahedron Letters. 2000 Feb 26;41(9):1351–1354.
Published In
Tetrahedron Letters
DOI
ISSN
0040-4039
Publication Date
February 26, 2000
Volume
41
Issue
9
Start / End Page
1351 / 1354
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry