A novel microbial metabolite, activator of low density lipoprotein receptor promoter


Journal Article

The organic extract of the fermentation broth of a Micromonospora microorganism was found to contain SCH 351448 (1), the monosodium salt of a macrocyclic dilactone containing two identical diacids. The structure and relative stereochemistry were established by single-crystal X-ray analysis. SCH 351448 is a novel ionophoric compound and is a weak activator of low density lipoprotein receptor (LDL-R) promoter with an IC50 of 25 μM. (C) 2000 Elsevier Science Ltd.

Full Text

Duke Authors

Cited Authors

  • Hegde, VR; Puar, MS; Dai, P; Patel, M; Gullo, VP; Das, PR; Bond, RW; McPhail, AT

Published Date

  • February 26, 2000

Published In

Volume / Issue

  • 41 / 9

Start / End Page

  • 1351 - 1354

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/S0040-4039(99)02291-1

Citation Source

  • Scopus