Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold.
We measured initial seizure threshold by means of a structured stimulus dosage titration procedure in a clinical sample of 111 depressed patients undergoing brief-pulse, constant-current electroconvulsive therapy (ECT). Initial seizure threshold was approximately 60 millicoumbs (mc) (10 Joules) on average, but varied widely (6-fold) across patients. Initial seizure threshold was predicted by four variables: electrode placement (higher with bilateral), gender (higher in men), age (higher with increasing age), and dynamic impedance (inverse relationship). Use of neuroleptic medication was associated with a lower seizure threshold. EEG seizure duration was inversely related to initial seizure threshold, but no other relations with seizure duration were found. These findings may have important clinical implications for stimulus dosing strategies in ECT.
Duke Scholars
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sensory Thresholds
- Retrospective Studies
- Psychiatry
- Psychiatric Status Rating Scales
- Premedication
- Middle Aged
- Male
- Humans
- Female
- Evoked Potentials
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sensory Thresholds
- Retrospective Studies
- Psychiatry
- Psychiatric Status Rating Scales
- Premedication
- Middle Aged
- Male
- Humans
- Female
- Evoked Potentials