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ECT seizure therapeutic adequacy.

Publication ,  Journal Article
Krystal, AD; Weiner, RD
Published in: Convuls Ther
June 1994

From the beginnings of convulsive therapy, the need for some way to assess the therapeutic adequacy of individual treatments has been apparent. Recent work suggests that seizure therapeutic adequacy and adverse effects are dependent on the extent to which the stimulus exceeds the seizure threshold (relative stimulus intensity). Applying this information in clinical practice is problematic because of the variable rise in the seizure threshold that takes place over the treatment course. Attributes of the ictal electroencephalogram (EEG) show promise for alleviating this problem by serving as a marker of relative stimulus intensity. Obstacles that need to be overcome in order to implement ictal EEG indices as a relative stimulus intensity marker in clinical practice are discussed and include artifacts, how to determine a threshold for deciding adequacy, variation in technique between sites, and inter-individual EEG variation; some strategies for overcoming these hurdles are described. It is anticipated that an ictal EEG algorithm that addresses these issues is likely to be of substantial clinical benefit in the practice of electroconvulsive therapy.

Duke Scholars

Published In

Convuls Ther

ISSN

0749-8055

Publication Date

June 1994

Volume

10

Issue

2

Start / End Page

153 / 164

Location

United States

Related Subject Headings

  • Humans
  • Electroencephalography
  • Electroconvulsive Therapy
  • Biomarkers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krystal, A. D., & Weiner, R. D. (1994). ECT seizure therapeutic adequacy. Convuls Ther, 10(2), 153–164.
Krystal, A. D., and R. D. Weiner. “ECT seizure therapeutic adequacy.Convuls Ther 10, no. 2 (June 1994): 153–64.
Krystal AD, Weiner RD. ECT seizure therapeutic adequacy. Convuls Ther. 1994 Jun;10(2):153–64.
Krystal, A. D., and R. D. Weiner. “ECT seizure therapeutic adequacy.Convuls Ther, vol. 10, no. 2, June 1994, pp. 153–64.
Krystal AD, Weiner RD. ECT seizure therapeutic adequacy. Convuls Ther. 1994 Jun;10(2):153–164.

Published In

Convuls Ther

ISSN

0749-8055

Publication Date

June 1994

Volume

10

Issue

2

Start / End Page

153 / 164

Location

United States

Related Subject Headings

  • Humans
  • Electroencephalography
  • Electroconvulsive Therapy
  • Biomarkers