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The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy.

Publication ,  Journal Article
Krystal, AD; Zaidman, C; Greenside, HS; Weiner, RD; Coffey, CE
Published in: Electroencephalogr Clin Neurophysiol
December 1997

Attributes of the electroencephalogram (EEG) recorded during electroconvulsive therapy (ECT) seizures appear promising for decreasing the uncertainty that exists about how to define a therapeutically adequate seizure. In the present report we study whether one promising and not yet tested ictal EEG measure, the largest Lyapunov exponent (lambda1), is useful in this regard. We calculated lambda1 from 2 channel ictal EEG data recorded in 25 depressed subjects who received right unilateral ECT. We studied the relationship of lambda1 to treatment therapeutic outcome and to an indirect measure of treatment therapeutic potency, the extent to which the stimulus intensity exceeds the seizure threshold. We found lambda1 could be reliably calculated from ictal EEG data and that the global mean, maximum, and standard deviation of lambda1 were smaller in the more therapeutically potent moderately suprathreshold ECT and in therapeutic responders. These results imply a more predictable or consistent pattern of EEG seizure activity over time in more therapeutically effective ECT seizures. These findings also suggest the promise of lambda1 as a marker of ECT seizure therapeutic adequacy and build on our previous work suggesting that lambda1 may be useful for classifying seizures and for reflecting the relative physiologic impact of seizure activity.

Duke Scholars

Published In

Electroencephalogr Clin Neurophysiol

DOI

ISSN

0013-4694

Publication Date

December 1997

Volume

103

Issue

6

Start / End Page

599 / 606

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Reproducibility of Results
  • Middle Aged
  • Humans
  • Electroencephalography
  • Electroconvulsive Therapy
  • Depression
  • Aged
  • Adult
 

Citation

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Krystal, A. D., Zaidman, C., Greenside, H. S., Weiner, R. D., & Coffey, C. E. (1997). The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy. Electroencephalogr Clin Neurophysiol, 103(6), 599–606. https://doi.org/10.1016/s0013-4694(97)00062-x
Krystal, A. D., C. Zaidman, H. S. Greenside, R. D. Weiner, and C. E. Coffey. “The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy.Electroencephalogr Clin Neurophysiol 103, no. 6 (December 1997): 599–606. https://doi.org/10.1016/s0013-4694(97)00062-x.
Krystal AD, Zaidman C, Greenside HS, Weiner RD, Coffey CE. The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy. Electroencephalogr Clin Neurophysiol. 1997 Dec;103(6):599–606.
Krystal, A. D., et al. “The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy.Electroencephalogr Clin Neurophysiol, vol. 103, no. 6, Dec. 1997, pp. 599–606. Pubmed, doi:10.1016/s0013-4694(97)00062-x.
Krystal AD, Zaidman C, Greenside HS, Weiner RD, Coffey CE. The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy. Electroencephalogr Clin Neurophysiol. 1997 Dec;103(6):599–606.

Published In

Electroencephalogr Clin Neurophysiol

DOI

ISSN

0013-4694

Publication Date

December 1997

Volume

103

Issue

6

Start / End Page

599 / 606

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Reproducibility of Results
  • Middle Aged
  • Humans
  • Electroencephalography
  • Electroconvulsive Therapy
  • Depression
  • Aged
  • Adult