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The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study.

Publication ,  Journal Article
Krystal, AD; Weiner, RD; McCall, WV; Shelp, FE; Arias, R; Smith, P
Published in: Biol Psychiatry
December 1, 1993

Recent evidence suggests that electroconvulsive therapy (ECT) efficacy depends upon both electrode placement and the degree to which stimulus dosage exceeds seizure threshold (T), and not simply on surpassing a minimum seizure duration as has been assumed. In light of these findings and studies reporting ictal electroencephalogram (EEG) differences between bilateral and unilateral ECT, we performed this 19-subject intraindividual crossover study of the effects of dose and electrode placement on the ictal EEG. We found ictal EEG evidence of greater seizure intensity with bilateral than unilateral ECT and with higher dosage (2.25 T) compared with barely suprathreshold stimuli. Seizure duration was not longer with bilateral than unilateral ECT and actually decreased with increased dose. A number of ictal EEG variables separated the unilateral 2.25 T and unilateral T conditions, which reportedly differ in efficacy, and therefore, these EEG measures show promise as markers of treatment adequacy.

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Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

December 1, 1993

Volume

34

Issue

11

Start / End Page

759 / 767

Location

United States

Related Subject Headings

  • Psychiatry
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electroencephalography
  • Electrodes
  • Electroconvulsive Therapy
  • Depressive Disorder
  • Brain
 

Citation

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Krystal, A. D., Weiner, R. D., McCall, W. V., Shelp, F. E., Arias, R., & Smith, P. (1993). The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study. Biol Psychiatry, 34(11), 759–767. https://doi.org/10.1016/0006-3223(93)90064-k
Krystal, A. D., R. D. Weiner, W. V. McCall, F. E. Shelp, R. Arias, and P. Smith. “The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study.Biol Psychiatry 34, no. 11 (December 1, 1993): 759–67. https://doi.org/10.1016/0006-3223(93)90064-k.
Krystal AD, Weiner RD, McCall WV, Shelp FE, Arias R, Smith P. The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study. Biol Psychiatry. 1993 Dec 1;34(11):759–67.
Krystal, A. D., et al. “The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study.Biol Psychiatry, vol. 34, no. 11, Dec. 1993, pp. 759–67. Pubmed, doi:10.1016/0006-3223(93)90064-k.
Krystal AD, Weiner RD, McCall WV, Shelp FE, Arias R, Smith P. The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study. Biol Psychiatry. 1993 Dec 1;34(11):759–767.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

December 1, 1993

Volume

34

Issue

11

Start / End Page

759 / 767

Location

United States

Related Subject Headings

  • Psychiatry
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electroencephalography
  • Electrodes
  • Electroconvulsive Therapy
  • Depressive Disorder
  • Brain