Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder.
Journal Article (Review)
Most patients with major depression have increased 24-hour urinary free cortisol and cortisol nonsuppression after dexamethasone administration, which are cornerstones of a diagnosis of Cushing's syndrome. Similarly, Cushing's syndrome patients often suffer from major psychiatric syndromes, most often depression. These similarities between the two conditions sometimes make it difficult to differentiate them and have led some investigators to suggest they are two points on a spectrum of endocrinologic dysfunction. This article reviews the literature comparing Cushing's syndrome and primary affective disorder and presents two cases that illustrate just how closely these diseases may resemble one another.
Full Text
Duke Authors
Cited Authors
- Krystal, A; Krishnan, KR; Raitiere, M; Poland, R; Ritchie, JC; Dunnick, NR; Hanada, K; Nemeroff, CB
Published Date
- 1990
Published In
Volume / Issue
- 2 / 1
Start / End Page
- 34 - 43
PubMed ID
- 1967010
Pubmed Central ID
- 1967010
International Standard Serial Number (ISSN)
- 0895-0172
Digital Object Identifier (DOI)
- 10.1176/jnp.2.1.34
Language
- eng
Conference Location
- United States