Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder.

Journal Article (Journal Article;Review)

Most patients with major depression have increased 24-hour urinary free cortisol and cortisol nonsuppression after dexamethasone administration, which are cornerstones of a diagnosis of Cushing's syndrome. Similarly, Cushing's syndrome patients often suffer from major psychiatric syndromes, most often depression. These similarities between the two conditions sometimes make it difficult to differentiate them and have led some investigators to suggest they are two points on a spectrum of endocrinologic dysfunction. This article reviews the literature comparing Cushing's syndrome and primary affective disorder and presents two cases that illustrate just how closely these diseases may resemble one another.

Full Text

Duke Authors

Cited Authors

  • Krystal, A; Krishnan, KR; Raitiere, M; Poland, R; Ritchie, JC; Dunnick, NR; Hanada, K; Nemeroff, CB

Published Date

  • 1990

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 34 - 43

PubMed ID

  • 1967010

International Standard Serial Number (ISSN)

  • 0895-0172

Digital Object Identifier (DOI)

  • 10.1176/jnp.2.1.34


  • eng

Conference Location

  • United States