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T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients.

Publication ,  Journal Article
Alam, SM; Clark, JS; Leech, V; Whitford, P; George, WD; Campbell, AM
Published in: Immunol Lett
February 15, 1992

The quantitative distribution and phenotype of gamma/delta lymphocytes in the peripheral blood (PBL), tumour draining lymph node (LNL) and tumour infiltrating lymphocytes (TIL) from breast carcinoma patients were determined by one- and two-colour flow cytometry. The TCR-gamma/delta + cells generally expressed the T cell lineage antigen CD3. The proportions of such cells were variable but generally small from all the three sources. Phenotypic analysis revealed that the CD8 marker was consistently and predominantly observed on gamma/delta + CD3+ cells in the tumour infiltrate, whereas CD4 expression, while generally low, was noted on a significant percentage (median 10%) of LNL gamma/delta + lymphocytes. In both PBL and LNL the predominant gamma/delta cell population was CD4-8-.

Duke Scholars

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

February 15, 1992

Volume

31

Issue

3

Start / End Page

279 / 283

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell
  • Lymphocytes, Tumor-Infiltrating
  • Lymph Nodes
  • Immunophenotyping
  • Immunology
  • Humans
  • Flow Cytometry
 

Citation

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Alam, S. M., Clark, J. S., Leech, V., Whitford, P., George, W. D., & Campbell, A. M. (1992). T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients. Immunol Lett, 31(3), 279–283. https://doi.org/10.1016/0165-2478(92)90127-a
Alam, S. M., J. S. Clark, V. Leech, P. Whitford, W. D. George, and A. M. Campbell. “T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients.Immunol Lett 31, no. 3 (February 15, 1992): 279–83. https://doi.org/10.1016/0165-2478(92)90127-a.
Alam SM, Clark JS, Leech V, Whitford P, George WD, Campbell AM. T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients. Immunol Lett. 1992 Feb 15;31(3):279–83.
Alam, S. M., et al. “T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients.Immunol Lett, vol. 31, no. 3, Feb. 1992, pp. 279–83. Pubmed, doi:10.1016/0165-2478(92)90127-a.
Alam SM, Clark JS, Leech V, Whitford P, George WD, Campbell AM. T cell receptor gamma/delta expression on lymphocyte populations of breast cancer patients. Immunol Lett. 1992 Feb 15;31(3):279–283.
Journal cover image

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

February 15, 1992

Volume

31

Issue

3

Start / End Page

279 / 283

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell
  • Lymphocytes, Tumor-Infiltrating
  • Lymph Nodes
  • Immunophenotyping
  • Immunology
  • Humans
  • Flow Cytometry