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Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients.

Publication ,  Journal Article
Whitford, P; Alam, SM; George, WD; Campbell, AM
Published in: Eur J Cancer
1992

The phenotype and activation status of lymphocytes from the peripheral blood and axillary lymph nodes of 40 patients with breast cancer were analysed using flow cytometry and compared with lymphocytes from the blood and lymph nodes of 7 control subjects. There was little difference in the overall proportions of T and B lymphocytes but there was a much larger population of B cells bearing surface IgG and a greater number of CD4+ helper T cells, particularly in the regional nodes, in the breast cancer patients. Many more T cells in the cancer patients were found to be carrying the HLA DR and Tac antigens. The axillary lymph nodes were the major site of B cells and CD4+ T cells whilst the primary tumour was the source of the CD8+ suppressor/cytotoxic T cells. Any immune response appeared to be largely loco-regional and may therefore destroyed by conventional surgery or radiotherapy.

Duke Scholars

Published In

Eur J Cancer

DOI

ISSN

0959-8049

Publication Date

1992

Volume

28

Issue

2-3

Start / End Page

350 / 356

Location

England

Related Subject Headings

  • Receptors, Transferrin
  • Receptors, Interleukin-2
  • Oncology & Carcinogenesis
  • Lymphocytes
  • Lymph Nodes
  • Immunoglobulin G
  • Humans
  • HLA-DR Antigens
  • Flow Cytometry
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Whitford, P., Alam, S. M., George, W. D., & Campbell, A. M. (1992). Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients. Eur J Cancer, 28(2–3), 350–356. https://doi.org/10.1016/s0959-8049(05)80052-8
Whitford, P., S. M. Alam, W. D. George, and A. M. Campbell. “Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients.Eur J Cancer 28, no. 2–3 (1992): 350–56. https://doi.org/10.1016/s0959-8049(05)80052-8.
Whitford P, Alam SM, George WD, Campbell AM. Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients. Eur J Cancer. 1992;28(2–3):350–6.
Whitford, P., et al. “Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients.Eur J Cancer, vol. 28, no. 2–3, 1992, pp. 350–56. Pubmed, doi:10.1016/s0959-8049(05)80052-8.
Whitford P, Alam SM, George WD, Campbell AM. Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients. Eur J Cancer. 1992;28(2–3):350–356.
Journal cover image

Published In

Eur J Cancer

DOI

ISSN

0959-8049

Publication Date

1992

Volume

28

Issue

2-3

Start / End Page

350 / 356

Location

England

Related Subject Headings

  • Receptors, Transferrin
  • Receptors, Interleukin-2
  • Oncology & Carcinogenesis
  • Lymphocytes
  • Lymph Nodes
  • Immunoglobulin G
  • Humans
  • HLA-DR Antigens
  • Flow Cytometry
  • Female