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Altered lymphocyte populations in tumour invaded nodes of breast cancer patients.

Publication ,  Journal Article
Alam, SM; Clark, JS; George, WD; Campbell, AM
Published in: Immunol Lett
March 1993

Lymphocytes from matched pairs of tumour-invaded and tumour-free lymph nodes from 22 stage II breast cancer patients have been analysed for expression of phenotypic and activation markers by flow cytometry. Although the relative proportions of T and B lymphocytes were similar in the two nodes, significant differences in the distribution of T cell subsets were observed between nodes that were invaded and those that were not. The CD4/CD8 ratio was markedly depressed in tumour invaded nodes (P < 0.001). This was due to an increase in the number of CD8+ T cells (P < 0.001) and a decrease in the CD4+ T cell population (P = 0.008) in invaded nodes in comparison with tumour-free nodes. The percentage of CD8+ T cells expressing HLA DR (P = 0.023) and IL-2 receptors (Tac) (P = 0.029) was significantly higher in invaded nodes and, while CD4+ T cells expressing HLA DR (P = 0.036) were also in a higher proportion of Tac expressing CD4+ T cells failed to reach significance. Although invaded nodes in a few patients were found to have a higher percentage of IgG-expressing B cells, no significant differences were observed between the two groups of nodes. These results suggest that the presence of metastatic tumour cells in a lymph node is associated with specific alterations in the T cell population.

Duke Scholars

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

March 1993

Volume

35

Issue

3

Start / End Page

229 / 234

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Receptors, Interleukin-2
  • Lymphocyte Activation
  • Lymphatic Metastasis
  • Lymph Nodes
  • Immunophenotyping
  • Immunology
  • Humans
  • HLA-DR Antigens
 

Citation

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Alam, S. M., Clark, J. S., George, W. D., & Campbell, A. M. (1993). Altered lymphocyte populations in tumour invaded nodes of breast cancer patients. Immunol Lett, 35(3), 229–234. https://doi.org/10.1016/0165-2478(93)90187-7
Alam, S. M., J. S. Clark, W. D. George, and A. M. Campbell. “Altered lymphocyte populations in tumour invaded nodes of breast cancer patients.Immunol Lett 35, no. 3 (March 1993): 229–34. https://doi.org/10.1016/0165-2478(93)90187-7.
Alam SM, Clark JS, George WD, Campbell AM. Altered lymphocyte populations in tumour invaded nodes of breast cancer patients. Immunol Lett. 1993 Mar;35(3):229–34.
Alam, S. M., et al. “Altered lymphocyte populations in tumour invaded nodes of breast cancer patients.Immunol Lett, vol. 35, no. 3, Mar. 1993, pp. 229–34. Pubmed, doi:10.1016/0165-2478(93)90187-7.
Alam SM, Clark JS, George WD, Campbell AM. Altered lymphocyte populations in tumour invaded nodes of breast cancer patients. Immunol Lett. 1993 Mar;35(3):229–234.
Journal cover image

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

March 1993

Volume

35

Issue

3

Start / End Page

229 / 234

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Receptors, Interleukin-2
  • Lymphocyte Activation
  • Lymphatic Metastasis
  • Lymph Nodes
  • Immunophenotyping
  • Immunology
  • Humans
  • HLA-DR Antigens